Kamaeva O I, Reznikov Iu P, Pimenova N S, Dobritsyna L V
Klin Med (Mosk). 1998;76(2):33-5.
Antigliadin antibodies (AGA) mark celiac disease, but AGA are also encountered in IgA-nephritis, psoriasis, sickle-cell anemia, hepatic disorders, juvenile rheumatoid arthritis, autoimmune thyroidism and in persons who occupationally contact great amounts of wheat. AGA IgA and/or IgG were registered in 19 of 60 subjects (51 adults and 9 children) with various immunomediated diseases without symptoms of celiac disease: in 4 cases of chronic active hepatitis, in 2 of 4 cases of chronic persistent hepatitis, in 4 of 16 cases of rheumatoid arthritis, in 3 of 19 cases of IgA-deficiency, in 1 of 8 cases of SLE, in 2 cases of postvaccine reaction, in all the single cases of juvenile rheumatoid arthritis, focal scleroderma, macroglobulinemia. IgA only occurred in in 6 patients, IgG- in 6 patients, both IgA and IgG in 7 patients. The most pronounced positive reaction to AGA was recorded in 8-year-old girl with juvenile rheumatoid arthritis. The emergence of AGA in immunomediated diseases may be attributed to the response to food protein in pathological conditions and is often unrelated closely with celiac disease.
抗麦醇溶蛋白抗体（AGA）是乳糜泻的标志物，但在IgA肾病、银屑病、镰状细胞贫血、肝脏疾病、青少年类风湿性关节炎、自身免疫性甲状腺疾病以及职业性接触大量小麦的人群中也会出现AGA。在60名（51名成人和9名儿童）患有各种免疫介导疾病但无乳糜泻症状的受试者中，有19名检测到AGA IgA和/或IgG：4例慢性活动性肝炎、4例慢性持续性肝炎中的2例、16例类风湿性关节炎中的4例、19例IgA缺乏症中的3例、8例系统性红斑狼疮中的1例、2例疫苗接种后反应、所有青少年类风湿性关节炎、局限性硬皮病、巨球蛋白血症的单例。仅IgA出现于6例患者，IgG出现于6例患者，IgA和IgG均出现于7例患者。在一名患有青少年类风湿性关节炎的8岁女孩中记录到对AGA最明显的阳性反应。免疫介导疾病中AGA的出现可能归因于病理状态下对食物蛋白的反应，且通常与乳糜泻关系不大。
