al-Fahim A, Hoffmann G W
Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Immunol Cell Biol. 1998 Feb;76(1):27-33. doi: 10.1046/j.1440-1711.1998.00711.x.
Using an ELISA assay and inhibition of antibody mediated cytotoxicity we found that there was a higher level of anti-antiself activity in B6 anti-BALB/c alloimmune mice than in BALB/c anti-B6 mice. In contrast, when an inhibition of cellular cytotoxicity assay was used to assay for the activity, similar levels of anti-antiself antibodies were seen in B6 anti-BALB/c and BALB/c anti-B6 sera. Anti-antiself antibodies in alloimmune sera are not absorbed by the cellular immunogen as readily as are anti-foreign antibodies. These results are interpreted in terms of anti-antiself antibodies being directed mainly against T cell receptors specific for self. Anti-antiself antibodies are found also in old B6 mice, that are also known to make autoantibodies.
通过酶联免疫吸附测定（ELISA）和抗体介导的细胞毒性抑制实验，我们发现，与BALB/c抗B6小鼠相比，B6抗BALB/c同种免疫小鼠中存在更高水平的抗自身抗体活性。相反，当使用细胞毒性抑制实验来检测活性时，在B6抗BALB/c和BALB/c抗B6血清中观察到相似水平的抗自身抗体。同种免疫血清中的抗自身抗体不像抗外源抗体那样容易被细胞免疫原吸收。这些结果可以解释为抗自身抗体主要针对自身特异性T细胞受体。在老年B6小鼠中也发现了抗自身抗体，已知这些小鼠也会产生自身抗体。
