Wolf R, Wolf D, Ruocco V
Maccabee Dermatologic Outpatient Clinic, Tel-Aviv University, Israel.
J Eur Acad Dermatol Venereol. 1998 Mar;10(2):103-17.
Since its discovery and isolation the importance of vitamin E in maintaining normal physiologic processes and its value in treating various disease states have been the subject of much controversy. It was our intention to review and highlight some of the arguments and problems regarding the usefulness of vitamin E and to try to put them into proper perspective. The major area of interest concerning vitamin E lies essentially in its role in preventing damage caused by free radicals. The latter are now known to play an important role in radiation induced carcinogenesis, photoaging and photosensitization. The chemistry of vitamin E, its physiological function as a major antioxidant and its interaction with other antioxidants are described by the sum of animal studies, in vitro research and epidemiological investigations. In preparing the current data, it appeared that despite the controversy and conflicting results the body of literature as a whole judges vitamin E to be useful as an antioxidant. Although, in principle, the use of vitamin E can be quite advantageous, the manner of its administration, especially regarding topical application, remains unclear.
自维生素E被发现和分离以来，其在维持正常生理过程中的重要性以及在治疗各种疾病状态中的价值一直备受争议。我们的目的是回顾并强调一些关于维生素E效用的论点和问题，并试图正确看待它们。关于维生素E的主要关注领域基本上在于其在预防自由基造成损害方面的作用。现在已知自由基在辐射诱导的致癌作用、光老化和光致敏中起重要作用。动物研究、体外研究和流行病学调查的综合结果描述了维生素E的化学性质、其作为主要抗氧化剂的生理功能以及它与其他抗氧化剂的相互作用。在整理当前数据时发现，尽管存在争议和相互矛盾的结果，但总体文献认为维生素E作为抗氧化剂是有用的。虽然原则上使用维生素E可能相当有益，但其给药方式，尤其是局部应用方面，仍不明确。
