Wozniak G, Dapper F, Schindler E, Akintürk H, Zickmann B, Gehron J, Hehrlein F W
Department of Cardiovascular Surgery, Justus-Liebig University, Giessen, Germany.
Thorac Cardiovasc Surg. 1998 Feb;46(1):7-11. doi: 10.1055/s-2007-1010176.
Maintaining an adequate cerebral oxygen supply is a serious problem in aortic arch surgery. Deep hypothermic circulatory arrest is the most common method used for cerebral protection, but guarantees only a time-limited safety period. Based on experimental investigations, we applied selective cerebral perfusion via the innominate artery alone with only moderate hypothermia (28 degrees C) and without circulatory arrest in 25 consecutive patients undergoing surgical treatment of an aneurysm (n = 10) or acute type-A dissection (n = 15) involving the aortic valve and arch. In every case a test perfusion was carried out to assess whether the cerebral perfusion achieved would be adequate for the whole operation. In no case was the perfusion inadequate. As a new perioperative monitoring system, we used computer-aided topographical electroencephalometry (CATEEM). There were 18 male and 7 female patients, their age was 47.0 +/- 15.1 years (mean +/- SD). Mean time periods were 155.1 +/- 37.3 min for aortic cross-clamping, and 69.3 +/- 35 min for selective cerebral perfusion. Postoperatively, two patients (8%) revealed a temporary left-sided hemiparesis, and 4 patients (16%) died within 30 days. The overall mortality rate was 16% in a follow-up period of 24.2 +/- 9.5 months. In this small group the CATEEM monitoring enabled an intraoperative selection of patients with sufficient bihemispheric collateral circulation and therefore suitable for simple innominate artery perfusion.
在主动脉弓手术中,维持充足的脑氧供应是一个严峻的问题。深度低温循环停搏是最常用的脑保护方法,但仅能保证有限的安全时间。基于实验研究,我们对25例连续接受手术治疗的动脉瘤患者(n = 10)或累及主动脉瓣和主动脉弓的急性A型主动脉夹层患者(n = 15),仅采用中度低温(28摄氏度),通过无名动脉进行选择性脑灌注,且不进行循环停搏。在每种情况下,都进行了测试灌注以评估所实现的脑灌注是否足以完成整个手术。在任何情况下灌注都没有不足。作为一种新的围手术期监测系统,我们使用了计算机辅助脑地形图脑电图监测(CATEEM)。有18例男性和7例女性患者,年龄为47.0±15.1岁(平均值±标准差)。平均主动脉阻断时间为155.1±37.3分钟,选择性脑灌注时间为69.3±35分钟。术后,2例患者(8%)出现暂时性左侧偏瘫,4例患者(16%)在30天内死亡。在24.2±9.5个月的随访期内,总死亡率为16%。在这个小样本中,CATEEM监测能够在术中选择具有足够双侧半球侧支循环、因此适合单纯无名动脉灌注的患者。