Xue H, Xu N, Zhang C
Shanghai Institute of Metallurgy, Chinese Academy of Sciences, People's Republic of China.
Contraception. 1998 Jan;57(1):49-53. doi: 10.1016/s0010-7824(97)00207-2.
As an improvement to the use of the copper bearing intrauterine device, indomethacin has been introduced to reduce the incidence of bleeding after insertion of the device. The effects of indomethacin on copper corrosion were studied in vitro in simulated uterine fluid. Electrochemical polarization resistance measurements indicated that indomethacin powder slightly increased the corrosion rate of copper if pH of the fluid was not under control and it did not change the corrosion rate if pH was adjusted daily to maintain some constancy. The experimental results for medication by indomethacin-releasing Silastic were basically the same as those with powdered indomethacin. X-ray diffraction showed that only cuprous oxide was formed on the copper substrated surface and that indomethacin did not affect the corrosion products. As scanning electron microscopy demonstrated, however, in the presence of indomethacin the oxide particles formed were found to be more coarse and dense than in the absence of indomethacin.
作为含铜宫内节育器使用方面的一项改进，已引入吲哚美辛以降低该节育器插入后出血的发生率。在模拟子宫液中对吲哚美辛对铜腐蚀的影响进行了体外研究。电化学极化电阻测量表明，如果液体的pH值不受控制，吲哚美辛粉末会略微提高铜的腐蚀速率；而如果每天调节pH值以保持一定恒定，则腐蚀速率不会改变。释放吲哚美辛的硅橡胶给药的实验结果与吲哚美辛粉末的实验结果基本相同。X射线衍射表明，在铜基底表面仅形成了氧化亚铜，且吲哚美辛不影响腐蚀产物。然而，扫描电子显微镜显示，在存在吲哚美辛的情况下，所形成的氧化物颗粒比不存在吲哚美辛时更粗糙且更致密。
