Harboe M
Institute of Immunology and Rheumatology, University of Oslo, Norway.
Dev Biol Stand. 1998;92:145-7.
Protective immunity to intracellular parasites is mediated by T cells. This response is complex, requiring activation of several subgroups of T cells and production of a balanced blend of cytokines to obtain protection rather than delayed hypersensitivity leading to tissue damage. To obtain additional, detailed information, on the kind, proper localization and specificity of the required immune response represents a major challenge in current vaccine research. Insufficient knowledge of these features is the major constraint for development as illustrated in tuberculosis and related mycobacterial infections.
对细胞内寄生虫的保护性免疫由T细胞介导。这种反应很复杂，需要激活几个T细胞亚群并产生平衡的细胞因子混合物以获得保护，而不是导致组织损伤的迟发型超敏反应。为了获得关于所需免疫反应的种类、适当定位和特异性的更多详细信息，是当前疫苗研究中的一项重大挑战。如在结核病和相关分枝杆菌感染中所示，对这些特征的了解不足是发展的主要制约因素。
