Gordijn M C, Beersma D G, Korte H J, Van den Hoofdakker R H
Department of Biological Psychiatry, University Clinic, Groningen, The Netherlands.
J Biol Rhythms. 1998 Apr;13(2):132-47. doi: 10.1177/074873098128999989.
In a crossover design, 8 nonseasonal depressed subjects, selected on the presence of diurnal mood variations, and 8 sex- and age-matched controls were exposed to dim light (< 10 lux) in the evening (18:00-21:00 h) and bright light (2500 lux) in the morning (ML, 6:00-9:00 h), to dim light in the morning and bright light in the evening (EL), or to dim light both in the evening and in the morning (DL) during 3 consecutive days in each of these conditions. There were no initial phase differences between depressed and healthy subjects in the timing of dim light melatonin onset, sleep termination, and body temperature. The phase shifts after EL and ML in both healthy and depressed subjects were as expected on the basis of a human phase response curve. On average, there was no therapeutic effect of the light exposure in the depressed patients. Two patients improved, but these effects do not seem to be related to shifts in the circadian system.
在一项交叉设计中，选取8名存在昼夜情绪变化的非季节性抑郁症患者以及8名性别和年龄匹配的对照者，让他们在每种条件下连续3天在傍晚（18:00 - 21:00）暴露于昏暗灯光（< 10勒克斯），早晨（6:00 - 9:00）暴露于明亮灯光（2500勒克斯）（晨亮组，ML），或在早晨暴露于昏暗灯光，傍晚暴露于明亮灯光（昏亮组，EL），或早晚均暴露于昏暗灯光（暗光组，DL）。抑郁症患者和健康受试者在昏暗灯光下褪黑素开始分泌时间、睡眠结束时间和体温方面，初始阶段没有差异。基于人类相位反应曲线，健康受试者和抑郁症患者在昏亮组和晨亮组后的相位变化符合预期。平均而言，光照对抑郁症患者没有治疗效果。有两名患者病情改善，但这些效果似乎与昼夜节律系统的变化无关。
