使用小剂量促胰液素联合蛙皮素作为人体胰腺功能的一项测试。
Use of caerulein with submaximal doses of secretin as a test of pancreatic function in man.
作者信息
Ribet A, Tournut R, Duffaut M, Vaysse N
出版信息
Gut. 1976 Jun;17(6):431-4. doi: 10.1136/gut.17.6.431.
Abstract
The pancreatic exocrine secretory response to different combinations of the pancreozymin-like peptide caerulein and secretin was studied in 110 healthy control subjects and 32 patients with pancreatic disease. A combination of 0-5 CU/kg-h secretin and 75 ng/kg-h caerulein provided maximal or near-maximal stimulation of the secretion of both bicarbonate and pancreatic enzymes. The combination of stimulant peptides in the above doses was found to give excellent separation between the secretion of bicarbonate, lipase, and chymotrypsin of the control group and patients with chronic pancreatitis. A combination of caerulein and secretin represents a safe, reliable, and effective mean of stimulating pancreatic exocrine secretion for the purpose of testing pancreatic function.
摘要
在110名健康对照者和32名胰腺疾病患者中研究了促胰酶素样肽蛙皮素和促胰液素不同组合对胰腺外分泌反应的影响。0 - 5 CU/kg - h促胰液素与75 ng/kg - h蛙皮素联合使用可最大程度或接近最大程度地刺激碳酸氢盐和胰腺酶的分泌。发现上述剂量的刺激肽组合能使对照组与慢性胰腺炎患者的碳酸氢盐、脂肪酶和胰凝乳蛋白酶分泌有很好的区分。蛙皮素和促胰液素联合使用是一种安全、可靠且有效的刺激胰腺外分泌以检测胰腺功能的方法。
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