Gründer W, Biesold M, Wagner M, Werner A
Institut für Medizinische Physik und Biophysik, Medizinische Fakultät, Universität Leipzig, Germany.
Invest Radiol. 1998 Apr;33(4):193-202. doi: 10.1097/00004424-199804000-00001.
After intraarticular application of gadolinium (Gd)-DTPA the visualization cartilage surface roughness is limited because of diffusion into the cartilage. To improve the sensitivity of magnetic resonance (MR) arthrography to diagnose cartilage surface abnormalities, the authors have tested liposome-entrapped contrast agents.
Using paramagnetic contrast agents (Gd-DTPA and manganese chloride) free and entrapped in liposomes, respectively, high resolution MR imaging investigations were performed at 7.1 tesla on intact pig temporomandibular and rabbit knee joints.
After intraarticular injection of the liposome-entrapped contrast agents an excellent contrast between cartilage surface and joint space was achieved. Diffusion of the contrast agent into the cartilage layer was prevented and the visualization of the cartilage surface was improved markedly. Small mechanically and enzymatically induced cartilage lesions could be assessed reliably.
Intraarticular injection of liposome-entrapped contrast agents can improve the potential of MR arthrography concerning the detection of early osteoarthritic cartilage changes.
关节腔内注射钆（Gd）-二乙三胺五乙酸（DTPA）后，由于造影剂扩散进入软骨，软骨表面粗糙度的可视化受到限制。为提高磁共振（MR）关节造影诊断软骨表面异常的敏感性，作者对脂质体包裹的造影剂进行了测试。
分别使用游离和顺磁性造影剂（Gd-DTPA和氯化锰）包裹于脂质体中，在7.1特斯拉对完整的猪颞下颌关节和兔膝关节进行高分辨率MR成像研究。
关节腔内注射脂质体包裹的造影剂后，软骨表面与关节间隙之间形成了极佳的对比。造影剂向软骨层的扩散得到了阻止，软骨表面的可视化明显改善。可以可靠地评估小的机械性和酶诱导性软骨损伤。
关节腔内注射脂质体包裹的造影剂可提高MR关节造影在检测早期骨关节炎软骨变化方面的潜力。
