Bashir A, Gray M L, Boutin R D, Burstein D
Department of Radiology, Charles A. Dana Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Radiology. 1997 Nov;205(2):551-8. doi: 10.1148/radiology.205.2.9356644.
To investigate the feasibility of applying magnetic resonance (MR) imaging with use of an anionic compound, Gd(DTPA)2- (gadolinium diethylenetriamine-pentaacetic acid), for measuring glycosaminoglycan concentration in human cartilage in clinical studies.
Penetration of Gd(DTPA)2- into cartilage was monitored through sequential T1-calculated images obtained after intraarticular (n = 2) or intravenous (n = 2) injection. T1-weighted and T1-calculated image series were then obtained in seven volunteers (nine knees) after penetration of Gd-(DTPA)2- into cartilage. If T1 was heterogeneous on Gd(DTPA)(2-)-enhanced images, images were also obtained after penetration of the cartilage with the nonionic contrast agent, gadoteridol.
Gd(DTPA)2- penetrated cartilage from the articular surface after intraarticular injection and from both the articular surface and the subchondral bone after intravenous injection. The latter resulted in shorter overall penetration time. T1 values on Gd(DTPA)(2-)-enhanced images were homogeneous in four knees, but in five knees T1 differences of up to 30% were observed. These T1 differences were not seen in the presence of gadoteridol. These variations in T1 reflected about 50% variations in glycosaminoglycan.
The data suggest that Gd(DTPA)(2-)-enhanced MR imaging has potential for monitoring glycosaminoglycan content of cartilage in vivo.
探讨在临床研究中应用磁共振（MR）成像结合阴离子化合物钆喷酸葡胺（Gd(DTPA)2-）测量人体软骨中糖胺聚糖浓度的可行性。
通过关节内注射（n = 2）或静脉注射（n = 2）后获得的连续T1计算图像监测Gd(DTPA)2-进入软骨的情况。在Gd-(DTPA)2-进入软骨后，对7名志愿者（9个膝关节）获取T1加权和T1计算图像序列。如果在Gd(DTPA)(2-)-增强图像上T1不均匀，在用非离子型造影剂钆特醇穿透软骨后也获取图像。
关节内注射后，Gd(DTPA)2-从关节表面进入软骨；静脉注射后，Gd(DTPA)2-从关节表面和软骨下骨进入软骨。后者导致总体穿透时间更短。在Gd(DTPA)(2-)-增强图像上，4个膝关节的T1值均匀，但在5个膝关节中观察到T1差异高达30%。在存在钆特醇的情况下未观察到这些T1差异。这些T1变化反映了糖胺聚糖约50%的变化。
数据表明，Gd(DTPA)(2-)-增强MR成像在体内监测软骨糖胺聚糖含量方面具有潜力。
