Seidenberg M, Hermann B, Wyler A R, Davies K, Dohan F C, Leveroni C
Department of Psychology, Chicago Medical School, Illinois 60064, USA.
Neuropsychology. 1998 Apr;12(2):303-16. doi: 10.1037//0894-4105.12.2.303.
The nature, pattern, and degree of neuropsychological change following anterior temporal lobectomy (ATL) were examined as a function of the presence or absence of the syndrome of mesial temporal lobe epilepsy (MTLE). Fifty-four patients exhibited the syndrome of MTLE, while 34 patients were without the syndrome (non-MTLE). The test-retest performance of a group of 40 epilepsy patients who did not undergo surgery was used to derive regression-based estimates of test-retest change. Overall, the MTLE group did not show significant cognitive decline following ATL. In contrast, the left non-MTLE group showed significant declines on verbal memory, confrontation naming, and verbal conceptual ability. Further, verbal memory was the most substantial area of decline, and was independent of seizure outcome. Clinical and theoretical implications of these findings are discussed.
根据内侧颞叶癫痫（MTLE）综合征的有无，研究了前颞叶切除术（ATL）后神经心理变化的性质、模式和程度。54例患者表现出MTLE综合征，而34例患者无此综合征（非MTLE）。一组未接受手术的40例癫痫患者的重测表现用于得出基于回归的重测变化估计值。总体而言，MTLE组在ATL后未显示出明显的认知衰退。相比之下，左侧非MTLE组在言语记忆、对名命名和言语概念能力方面表现出显著下降。此外，言语记忆是下降最明显的领域，且与癫痫发作结果无关。讨论了这些发现的临床和理论意义。
