Rodríguez-Enríquez S, Moreno-Sánchez R
Departamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., México.
Arch Med Res. 1998 Spring;29(1):1-12.
Tumor cells show several modifications in their metabolism in comparison with normal cells. In particular, tumor cells show an accelerated glycolysis and a low O2 dependence, which are metabolic modifications involved in the resistance of many tumor cell lines to radiation. Thus, a strategy to enhance the radiosensitivity could be the transformation of the glycolytic metabolism of tumor cells into an oxidative type of metabolism, i.e., to induce the ATP supply to depend solely on oxidative phosphorylation. Therefore, this review emphasizes the relevance of oxidative phosphorylation on tumor cells regarding (a) its contribution to ATP supply for cell duplication during the proliferative phase, and (b) the possible therapeutic implications of having oxidative rather than glycolytic tumor cells.
与正常细胞相比，肿瘤细胞的代谢表现出多种改变。特别是，肿瘤细胞表现出糖酵解加速和低氧依赖性，这些代谢改变与许多肿瘤细胞系对辐射的抗性有关。因此，增强放射敏感性的一种策略可能是将肿瘤细胞的糖酵解代谢转变为氧化型代谢，即诱导ATP供应仅依赖于氧化磷酸化。因此，本综述强调氧化磷酸化对肿瘤细胞的相关性，涉及（a）其在增殖期对细胞复制的ATP供应的贡献，以及（b）具有氧化型而非糖酵解型肿瘤细胞的可能治疗意义。
