酵母双链RNA病毒的RNA依赖性RNA聚合酶中保守基序的功能
Functions of conserved motifs in the RNA-dependent RNA polymerase of a yeast double-stranded RNA virus.
作者信息
Routhier E, Bruenn J A
机构信息
Department of Biological Sciences, SUNY-Buffalo, New York 14260, USA.
出版信息
J Virol. 1998 May;72(5):4427-9. doi: 10.1128/JVI.72.5.4427-4429.1998.
Abstract
At least eight conserved motifs are visible in the totivirus RNA-dependent RNA polymerase (RDRP). We have systematically altered each of these in the Saccharomyces cerevisiae double-stranded RNA virus ScVL1 by substituting the conserved motifs from a giardiavirus. The results help define the conserved regions of the RDRP involved in polymerase function and those essential for other reasons.
摘要
在全病毒RNA依赖性RNA聚合酶（RDRP）中至少可见八个保守基序。我们通过用贾第虫病毒的保守基序替换酿酒酵母双链RNA病毒ScVL1中的每一个，对这些基序进行了系统改造。这些结果有助于确定RDRP中参与聚合酶功能的保守区域以及因其他原因而必不可少的区域。
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本文引用的文献
1
In vitro selection of packaging sites in a double-stranded RNA virus.双链RNA病毒中包装位点的体外筛选
J Virol. 1997 Mar;71(3):2157-62. doi: 10.1128/JVI.71.3.2157-2162.1997.
2
Elimination of L-A double-stranded RNA virus of Saccharomyces cerevisiae by expression of gag and gag-pol from an L-A cDNA clone.通过从L-A cDNA克隆表达gag和gag-pol消除酿酒酵母的L-A双链RNA病毒
J Virol. 1993 May;67(5):2764-71. doi: 10.1128/JVI.67.5.2764-2771.1993.
3
A closely related group of RNA-dependent RNA polymerases from double-stranded RNA viruses.来自双链RNA病毒的一组密切相关的RNA依赖性RNA聚合酶。
Nucleic Acids Res. 1993 Dec 11;21(24):5667-9. doi: 10.1093/nar/21.24.5667.
4
A cryptic RNA-binding domain in the Pol region of the L-A double-stranded RNA virus Gag-Pol fusion protein.L-A双链RNA病毒Gag-Pol融合蛋白Pol区域中的一个隐秘RNA结合结构域。
J Virol. 1994 Sep;68(9):6014-20. doi: 10.1128/JVI.68.9.6014-6020.1994.
5
Fungal virus capsids, cytoplasmic compartments for the replication of double-stranded RNA, formed as icosahedral shells of asymmetric Gag dimers.真菌病毒衣壳，即双链RNA复制的细胞质区室，由不对称Gag二聚体形成二十面体外壳。
J Mol Biol. 1994 Dec 2;244(3):255-8. doi: 10.1006/jmbi.1994.1726.
6
Packaging in a yeast double-stranded RNA virus.包装在酵母双链RNA病毒中。
J Virol. 1995 Mar;69(3):1917-9. doi: 10.1128/JVI.69.3.1917-1919.1995.
7
Cloning and sequencing of the preprotoxin-coding region of the yeast M1 double-stranded RNA.酵母M1双链RNA前原毒素编码区的克隆与测序
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8
A glycosylated protoxin in killer yeast: models for its structure and maturation.杀伤酵母中的一种糖基化原毒素：其结构与成熟的模型
Cell. 1983 Jan;32(1):169-80. doi: 10.1016/0092-8674(83)90507-x.
9
Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome.脊髓灰质炎病毒cDNA的分子克隆及病毒基因组完整核苷酸序列的测定。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4887-91. doi: 10.1073/pnas.78.8.4887.
10
Primary structure, gene organization and polypeptide expression of poliovirus RNA.脊髓灰质炎病毒RNA的一级结构、基因组织及多肽表达
Nature. 1981 Jun 18;291(5816):547-53. doi: 10.1038/291547a0.
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