1型人类免疫缺陷病毒原始分离株包膜糖蛋白对CCR5、CXCR4和CCR3的使用模式
Patterns of CCR5, CXCR4, and CCR3 usage by envelope glycoproteins from human immunodeficiency virus type 1 primary isolates.
作者信息
Bazan H A, Alkhatib G, Broder C C, Berger E A
机构信息
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0445, USA.
出版信息
J Virol. 1998 May;72(5):4485-91. doi: 10.1128/JVI.72.5.4485-4491.1998.
Abstract
Coreceptor usage by Envs from diverse primary human immunodeficiency virus type 1 isolates was analyzed by a vaccinia virus-based expression and assay system. Usage of recombinant CCR5 and CXCR4 correlated closely with fusogenicity toward macrophages and T-cell lines expressing endogenous coreceptors. Surprisingly, recombinant CCR3 was utilized by most primary and T-cell-line-adapted Envs. Endogenous CXCR4 in macrophages was functional as a coreceptor.
摘要
利用基于痘苗病毒的表达和检测系统，分析了来自多种原发性人类免疫缺陷病毒1型分离株的包膜蛋白（Env）对共受体的使用情况。重组CCR5和CXCR4的使用与对表达内源性共受体的巨噬细胞和T细胞系的融合活性密切相关。令人惊讶的是，大多数原发性和适应T细胞系的Env利用重组CCR3。巨噬细胞中的内源性CXCR4作为共受体发挥功能。
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