Asai T
Department of Anesthesiology, Kansai Medical University, Osaka, Japan.
Middle East J Anaesthesiol. 1998 Feb;14(4):259-66.
The effects of ingestion of digestion of digestible solids and liquids on gastric emptying of indigestible solids were studied. Thirty rats were allocated to one of five groups; in four groups, rats had been fasted for 24 h before the experiment, whereas in the fifth group, they had not been fasted. In all groups, ten steel balls (1.0 mm in diameter) were inserted through an orogastric cannula into the stomach under brief halothane anesthesia. In the four groups of fasted rats, one of the following substance was then given into the stomach: (1) 0.5 g digestible solids; (2) 1.0 ml saline; (3) 1.0 ml contrast medium (45% wv sodium diatrizoate); (4) no substance (control group). Three hours later, the number of balls which had passed into the intestine was counted. Ingestion of 0.5 g meal in fasted rats significantly delayed gastric emptying of steel balls (P < < 0.001), whereas there was no difference in gastric emptying of steel balls between fasted rats and fully fed rats. Ingestion of the contrast medium (P < < 0.001), but not that of saline, significantly delayed the emptying of the balls. Therefore, ingestion of digestible solids or liquids may delay gastric emptying of indigestible solids. Clinical implications of gastric emptying of indigestible solids are discussed.
研究了可消化固体和液体的摄入或消化对不可消化固体胃排空的影响。30只大鼠被分配到五组中的一组；在四组中，大鼠在实验前禁食24小时，而在第五组中，它们没有禁食。在所有组中，在短暂的氟烷麻醉下，通过口胃插管将10个钢球（直径1.0毫米）插入胃中。在四组禁食大鼠中，随后将以下物质之一注入胃中：(1) 0.5克可消化固体；(2) 1.0毫升生理盐水；(3) 1.0毫升造影剂（45%重量/体积泛影酸钠）；(4) 无物质（对照组）。三小时后，计算进入肠道的球的数量。禁食大鼠摄入0.5克食物显著延迟了钢球的胃排空（P << 0.001），而禁食大鼠和饱食大鼠之间钢球的胃排空没有差异。摄入造影剂（P << 0.001）而非生理盐水显著延迟了球的排空。因此，摄入可消化固体或液体可能会延迟不可消化固体的胃排空。讨论了不可消化固体胃排空的临床意义。
