Saab S, Corr M P, Weisman M H
Department of Medicine, University of California, San Diego Medical Center, 92103-8418, USA.
J Rheumatol. 1998 Apr;25(4):801-6.
To determine whether (1) corticosteroids cause pancreatitis in patients with systemic lupus erythematosus (SLE); (2) SLE pancreatitis occurs in the setting of a generalized SLE flare; and (3) corticosteroids can be used to treat SLE pancreatitis.
A total of 8 patients over a 10 year period with pancreatitis and SLE were identified retrospectively from a hospital database at the University of California San Diego Medical Center.
All 8 patients received therapeutic doses of corticosteroids as part of their treatment for SLE and pancreatitis. All patients manifested both clinical and biochemical resolution of their pancreatitis with the administration of corticosteroids. No patient in our study experienced immediate complications related to corticosteroids. Only 2 of the 8 patients manifested active concurrent systemic disease related to the SLE.
Corticosteroids do not cause pancreatitis in patients with SLE, and they should be administered during episodes of acute pancreatitis if clinically necessary. Pancreatitis does not tend to occur in the setting of a generalized SLE flare.
确定（1）皮质类固醇是否会导致系统性红斑狼疮（SLE）患者发生胰腺炎；（2）SLE胰腺炎是否在全身性SLE病情活动期出现；（3）皮质类固醇能否用于治疗SLE胰腺炎。
回顾性分析加利福尼亚大学圣地亚哥分校医学中心医院数据库，在10年期间共识别出8例患有胰腺炎和SLE的患者。
所有8例患者在治疗SLE和胰腺炎过程中均接受了治疗剂量的皮质类固醇。所有患者在使用皮质类固醇后胰腺炎的临床和生化指标均得到缓解。我们研究中的患者均未出现与皮质类固醇相关的即刻并发症。8例患者中只有2例表现出与SLE相关的活动性全身性疾病。
皮质类固醇不会导致SLE患者发生胰腺炎，如有临床需要，在急性胰腺炎发作期间应使用皮质类固醇。胰腺炎不太可能在全身性SLE病情活动期出现。
