Suarez F L, Furne J K, Springfield J, Levitt M D
Research Department, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA.
Gastroenterology. 1998 May;114(5):923-9. doi: 10.1016/s0016-5085(98)70311-7.
BACKGROUND & AIMS: Hydrogen sulfide is one of the main malodorous compounds in human flatus. This toxic gas also has been implicated in the pathogenesis of ulcerative colitis. Therefore, a treatment that reduces colonic H2S levels could be clinically useful in the treatment of flatus odor and of ulcerative colitis. In this study the ability of bismuth subsalicylate, a compound that binds H2S, to reduce H2S release in the colon, was tested.
Homogenates made from human and rat feces were incubated with and without bismuth subsalicylate, and gas production was measured. Fecal samples from 10 healthy subjects were analyzed before and after ingestion of bismuth subsalicylate (524 mg four times a day) for 3-7 days.
Fecal homogenates showed a dose-dependent relationship between the concentration of bismuth subsalicylate and H2S release. Treatment of subjects with bismuth subsalicylate produced a >95% reduction in fecal H2S release.
The ability of bismuth subsalicylate to dramatically reduce H2S could provide a clinically useful means of controlling fecal and/or flatus odor and of decreasing the putative injurious effects of H2S on the colonic mucosa.
硫化氢是人体屁中主要的恶臭化合物之一。这种有毒气体也被认为与溃疡性结肠炎的发病机制有关。因此，一种能降低结肠硫化氢水平的治疗方法在治疗屁臭和溃疡性结肠炎方面可能具有临床应用价值。在本研究中，测试了能结合硫化氢的碱式水杨酸铋减少结肠中硫化氢释放的能力。
将人和大鼠粪便制成的匀浆分别在有和没有碱式水杨酸铋的情况下进行孵育，并测量气体产生量。对10名健康受试者在摄入碱式水杨酸铋（每天4次，每次524毫克）3 - 7天前后的粪便样本进行分析。
粪便匀浆显示碱式水杨酸铋浓度与硫化氢释放之间存在剂量依赖关系。用碱式水杨酸铋治疗受试者可使粪便中硫化氢释放减少>95%。
碱式水杨酸铋显著降低硫化氢的能力可为控制粪便和/或屁臭以及减少硫化氢对结肠黏膜的假定有害作用提供一种临床有用的方法。
