Merup M, Moreno T C, Heyman M, Rönnberg K, Grandér D, Detlofsson R, Rasool O, Liu Y, Söderhäll S, Juliusson G, Gahrton G, Einhorn S
Radiumhemmet and the Childhood Cancer Research Unit, Department of Pediatrics, Karolinska Hospital, Stockholm, Sweden.
Blood. 1998 May 1;91(9):3397-400.
Deletions on the long arm of chromosome 6 are frequently found in acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphomas (NHL). We have used polymerase chain reaction analysis to study loss of heterozygosity of 16 microsatellite markers on chromosome 6 in 74 ALL and 54 NHL patients. Our results show that deletions of 6q in ALL are more frequent than what has been reported in previous studies, occurring in at least 32% of the patients. The corresponding figure for NHL patients is 7%. Our results define a region of minimal deletion in ALL of less than 500 kb between markers D6S1709 and D6S434. The common region of deletion in NHL is located telomeric of this region. Thus, two different tumor suppressor genes on chromosome 6q seem to be relevant for the development of lymphoid malignancies.
6号染色体长臂缺失在急性淋巴细胞白血病（ALL）和非霍奇金淋巴瘤（NHL）中经常被发现。我们使用聚合酶链反应分析研究了74例ALL患者和54例NHL患者6号染色体上16个微卫星标记的杂合性缺失。我们的结果显示，ALL中6q缺失比先前研究报道的更为频繁，至少在32%的患者中出现。NHL患者的相应数字为7%。我们的结果确定了ALL中最小缺失区域，位于标记D6S1709和D6S434之间小于500 kb处。NHL中常见的缺失区域位于该区域的端粒。因此，6号染色体q臂上的两个不同肿瘤抑制基因似乎与淋巴恶性肿瘤的发生有关。
