Resnick M I, Grayhack J T
Invest Urol. 1978 Mar;15(5):392-4.
Castrate male Sprague-Dawley rats were treated with either testosterone; testosterone and estradiol; testosterone, estradiol and 2-Bromo-alpha-Ergocryptine (CB-154), an inhibitor of prolactin secretion; or testosterone and CB-154. Estradiol potentiated testosterone-induced growth of the dorsal, lateral, and ventral prostate and this effect was not counteracted by CB-154. Estradiol only induced hypertrophy of the dorsal and ventral prostate, however, hyperplastic changes occurred in the lateral prostate.
对去势的雄性斯普拉格-道利大鼠分别用以下药物进行处理：睾酮；睾酮和雌二醇；睾酮、雌二醇和2-溴-α-麦角隐亭（CB-154，一种催乳素分泌抑制剂）；或睾酮和CB-154。雌二醇增强了睾酮诱导的背侧、外侧和腹侧前列腺的生长，且这种作用未被CB-154抵消。然而，雌二醇仅诱导背侧和腹侧前列腺肥大，而外侧前列腺发生了增生性变化。
