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Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain.

作者信息

Kowaltowski A J, Costa A D, Vercesi A E

机构信息

Departamento de Patologia Clinica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brazil.

出版信息

FEBS Lett. 1998 Mar 27;425(2):213-6. doi: 10.1016/s0014-5793(98)00231-2.

DOI:10.1016/s0014-5793(98)00231-2
PMID:9559650
Abstract

A variety of plant tissues contain an uncoupling mitochondrial protein (PUMP), recently described and characterized by our group. In this study we show that the inhibition of PUMP activity in potato tuber mitochondria significantly increases mitochondrial H2O2 generation, while PUMP substrates, such as linoleic acid, reduce mitochondrial H2O2 generation. This H2O2 generation occurred mainly by the dismutation of superoxide radicals formed through monoelectronic reduction of O2 by semiquinone forms of coenzyme Q. The results presented suggest that protection against mitochondrial oxidative stress may be a physiological role of PUMP.

摘要

相似文献

1
Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain.
FEBS Lett. 1998 Mar 27;425(2):213-6. doi: 10.1016/s0014-5793(98)00231-2.
2
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