解偶联蛋白2与代谢性疾病
Uncoupling protein 2 and metabolic diseases.
作者信息
Sreedhar Annapoorna, Zhao Yunfeng
机构信息
Department of Pharmacology, Toxicology & Neuroscience, LSU Health Sciences Center in Shreveport, Shreveport, LA 71130, USA.
Department of Pharmacology, Toxicology & Neuroscience, LSU Health Sciences Center in Shreveport, Shreveport, LA 71130, USA.
出版信息
Mitochondrion. 2017 May;34:135-140. doi: 10.1016/j.mito.2017.03.005. Epub 2017 Mar 25.
Abstract
Mitochondria are fascinating organelles involved in various cellular-metabolic activities that are integral for mammalian development. Although they perform diverse, yet interconnected functions, mitochondria are remarkably regulated by complex signaling networks. Therefore, it is not surprising that mitochondrial dysfunction is involved in plethora of diseases, including neurodegenerative and metabolic disorders. One of the many factors that lead to mitochondrial-associated metabolic diseases is the uncoupling protein-2, a family of mitochondrial anion proteins present in the inner mitochondrial membrane. Since their discovery, uncoupling proteins have attracted considerable attention due to their involvement in mitochondrial-mediated oxidative stress and energy metabolism. This review attempts to provide a summary of recent developments in the field of uncoupling protein 2 relating to mitochondrial associated metabolic diseases.
摘要
线粒体是参与各种细胞代谢活动的迷人细胞器，这些活动对哺乳动物发育至关重要。尽管线粒体执行着多样但相互关联的功能，但其受到复杂信号网络的显著调控。因此，线粒体功能障碍涉及包括神经退行性疾病和代谢紊乱在内的众多疾病也就不足为奇了。导致线粒体相关代谢疾病的众多因素之一是解偶联蛋白2，它是线粒体内膜中存在的一类线粒体阴离子蛋白。自发现以来，解偶联蛋白因其参与线粒体介导的氧化应激和能量代谢而备受关注。本综述试图总结解偶联蛋白2领域与线粒体相关代谢疾病有关的最新进展。
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