Chang G, McGarigle C, Spitzer T R, McAfee S L, Harris F, Piercy K, Goetz M N, Antin J H
Division of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Psychosom Med. 1998 Mar-Apr;60(2):163-7. doi: 10.1097/00006842-199803000-00009.
The purpose of this investigation is to test whether related bone marrow donors experience more distress from marrow donation than volunteer unrelated donors.
Participants in the study were 77 related and unrelated marrow donors who agreed to complete 11 pre- and 8 postdonation self report questionnaires. Related and unrelated donors were recruited from the Bone Marrow Transplant Programs at the Brigham and Women's Hospital and the Massachusetts General Hospital in Boston, MA. Additional unrelated donors were recruited from the American Red Cross-Carolinas and the Heart of America Bone Marrow Donor Registry in Kansas City, MO.
The 41 unrelated and 36 related marrow donors who participated in this prospective study had similar demographic backgrounds and predonation questionnaire results, although related donors endorsed more items on the Beck Depression Inventory, both before and after narrow harvesting. After narrow donation, related donors reported significantly more pain than unrelated donors (p = .0001).
It is unlikely that intraoperative events alone could account for the increased pain experienced by related donors. Related donors were more likely to experience moderate to severe physical pain after marrow donation than unrelated donors, on the basis of logistic regression analysis (odds ratio = 7.63; 95% confidence interval 2.74, 23.01).
本调查旨在测试亲属骨髓捐献者与非亲属志愿捐献者相比，在骨髓捐献过程中是否会经历更多痛苦。
该研究的参与者为77名亲属及非亲属骨髓捐献者，他们同意完成11份捐献前及8份捐献后的自我报告问卷。亲属及非亲属捐献者分别来自马萨诸塞州波士顿市布里格姆妇女医院和麻省总医院的骨髓移植项目。另外，非亲属捐献者还从美国红十字会卡罗莱纳分会以及密苏里州堪萨斯城的美国心脏地带骨髓捐献者登记处招募。
参与这项前瞻性研究的41名非亲属及36名亲属骨髓捐献者具有相似的人口统计学背景和捐献前问卷结果，不过亲属捐献者在骨髓采集前后的贝克抑郁量表上认可的项目更多。骨髓捐献后，亲属捐献者报告的疼痛明显多于非亲属捐献者（p = .0001）。
仅手术中的情况不太可能解释亲属捐献者所经历的疼痛增加。基于逻辑回归分析，亲属捐献者在骨髓捐献后比非亲属捐献者更有可能经历中度至重度身体疼痛（优势比 = 7.63；95%置信区间2.74, 23.01）。
