Labott S, Pfammatter A
Department of Psychiatry (MC 913), University of Illinois at Chicago, Chicago, IL, USA.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Bone Marrow Transplant. 2014 Jun;49(6):831-5. doi: 10.1038/bmt.2014.38. Epub 2014 Mar 17.
Previous research has begun to delineate the complicated reactions experienced by bone marrow and stem cell donors. The purpose of this study was to examine the influence of the donor-recipient relationship on the related donor's emotional reactions. Twenty-eight adult stem cell donors completed questionnaires before donation, 30 days post stem cell infusion, and 1 year after infusion. Questionnaires addressed the donor-recipient relationship, depression, mood, guilt and responsibility, self-esteem, ambivalence about donation and reactions to the donation itself. Results indicated that most donors reported little ambivalence about donation, and their reactions to the donation itself were generally positive. Closer and more positive donor-recipient relationships were associated with less anticipated guilt and responsibility if the transplant did not work. The relationships between the donor and the recipient did not change over time. Mood disturbance and depression were low overall, not related to the donor-recipient relationship, and did not significantly change over time. These results indicate that related stem cell donors are generally without significant emotional distress, and are comfortable with the donation process. Further, a more positive relationship with the recipient may help donors to avoid feeling guilty and responsible if the transplant does not work.
先前的研究已开始描绘骨髓和干细胞捐赠者所经历的复杂反应。本研究的目的是考察供受者关系对相关捐赠者情绪反应的影响。28名成年干细胞捐赠者在捐赠前、干细胞输注后30天以及输注后1年完成了问卷调查。问卷涉及供受者关系、抑郁、情绪、内疚感和责任感、自尊、对捐赠的矛盾心理以及对捐赠本身的反应。结果表明，大多数捐赠者表示对捐赠几乎没有矛盾心理，并且他们对捐赠本身的反应总体上是积极的。如果移植不成功，更亲密、更积极的供受者关系与较少的预期内疚感和责任感相关。供者与受者之间的关系并未随时间而改变。总体而言，情绪困扰和抑郁程度较低，与供受者关系无关，且未随时间发生显著变化。这些结果表明，相关干细胞捐赠者通常没有明显的情绪困扰，并且对捐赠过程感到安心。此外，如果移植不成功，与受者建立更积极的关系可能有助于捐赠者避免产生内疚感和责任感。
