Ishihara M, Ohno S, Ono H, Isogai E, Kimura K, Isogai H, Aoki K, Ishida T, Suzuki K, Kotake S, Hiraga Y
Department of Ophthalmology, Yokohama City University School of Medicine, Japan.
Graefes Arch Clin Exp Ophthalmol. 1998 Apr;236(4):280-4. doi: 10.1007/s004170050078.
Sarcoidosis is a multisystemic granulomatous disease of unknown etiology, while Lyme borreliosis is a multisystemic disorder caused by Borrelia burgdorferi. The purpose of this study is to evaluate the relationship between sarcoidosis and Lyme borreliosis in a region of Japan where Lyme borreliosis is endemic.
We determined the seroprevalence of anti-Borrelia burgdorferi antibodies as well as antibodies three Japanese Borrelia strains by enzyme-linked immunosorbent assay and dotblot assay using purified Borrelia-specific proteins in 46 patients with confirmed sarcoidosis and 150 controls (50 disease controls and 100 healthy controls) in Hokkaido, the affected region.
Fifteen patients with sarcoidosis (32.6%) tested positive for Borrelia spirochete in both assays, compared with two disease controls (4.0%) and two healthy controls (2.0%). The seroprevalence of anti-Borrelia antibodies in patients with sarcoidosis was much higher in the affected region than in the region in our previous study were Lyme borreliosis is non-endemic.
In a region where Lyme borreliosis is endemic, Borrelia infection may be partially associated with sarcoidosis.
结节病是一种病因不明的多系统肉芽肿性疾病，而莱姆病是由伯氏疏螺旋体引起的多系统疾病。本研究的目的是评估日本莱姆病流行地区结节病与莱姆病之间的关系。
我们在受影响地区北海道，采用酶联免疫吸附试验和斑点印迹试验，使用纯化的伯氏疏螺旋体特异性蛋白，测定了46例确诊结节病患者和150名对照者（50名疾病对照者和100名健康对照者）中抗伯氏疏螺旋体抗体以及针对三种日本伯氏疏螺旋体菌株的抗体的血清阳性率。
两种检测方法中，15例结节病患者（32.6%）检测出伯氏螺旋体呈阳性，相比之下，有2例疾病对照者（4.0%）和2例健康对照者（2.0%）呈阳性。与我们之前研究的莱姆病非流行地区相比，受影响地区结节病患者中抗伯氏疏螺旋体抗体的血清阳性率要高得多。
在莱姆病流行地区，伯氏疏螺旋体感染可能与结节病部分相关。
