Kimura K, Isogai E, Isogai H, Nishikawa T, Masuzawa T, Yoshikawa K, Kotake S, Ohno S, Fujii N
Department of Microbiology, Sapporo Medical University, Japan.
Clin Diagn Lab Immunol. 1995 Jan;2(1):53-6. doi: 10.1128/cdli.2.1.53-56.1995.
We studied 93 patients with unclassified uveitis from two regions in Japan (Hokkaido and Kanagawa) to assess the contribution of Borrelia species to this condition. The seroprevalence of antibody to Borrelia species was higher in patients from Hokkaido than in those from Kanagawa. The unclassified uveitis of seropositive patients was probably a complication of Lyme borreliosis since (i) the antibody titers were as high as those in clinically diagnosed Lyme disease patients, (ii) healthy controls from Hokkaido showed low seroprevalence in contrast with unclassified uveitis patients from Hokkaido, and (iii) the reaction pattern of antibodies in sera from patients with unclassified uveitis was the same as that in patients with Lyme disease. This is the first report to reveal the high risk of Lyme borreliosis in patients with unclassified uveitis in regions endemic for Lyme disease. In case of unclassified uveitis as well as in cases of inflammatory disease of unknown origin, Lyme disease should be taken into consideration, especially in regions in which Lyme diseases is endemic, even if it is reported only in animals.
我们对来自日本两个地区（北海道和神奈川）的93例未分类葡萄膜炎患者进行了研究，以评估疏螺旋体属对此病症的影响。北海道患者中针对疏螺旋体属的抗体血清阳性率高于神奈川的患者。血清阳性患者的未分类葡萄膜炎可能是莱姆病的并发症，因为（i）抗体滴度与临床诊断的莱姆病患者一样高，（ii）与北海道未分类葡萄膜炎患者相比，北海道的健康对照者血清阳性率较低，以及（iii）未分类葡萄膜炎患者血清中的抗体反应模式与莱姆病患者相同。这是第一份揭示在莱姆病流行地区未分类葡萄膜炎患者中莱姆病高风险的报告。对于未分类葡萄膜炎以及不明原因的炎症性疾病，应考虑莱姆病，尤其是在莱姆病流行的地区，即使仅在动物中报告过该病。
