Kraaijvanger Raisa, Veltkamp Marcel
Interstitial Lung Diseases Centre of Excellence, Department of Pulmonology, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.
Division of Hearth and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Microorganisms. 2022 Aug 15;10(8):1649. doi: 10.3390/microorganisms10081649.
(, formerly ) is considered to be a non-pathogenic resident of the human skin, as well as mucosal surfaces. However, it also has been demonstrated that plays a pathogenic role in diseases such as acne vulgaris or implant infections after orthopedic surgery. Besides a role in infectious disease, this bacterium also seems to harbor immunomodulatory effects demonstrated by studies using to enhance anti-tumor activity in various cancers or vaccination response. Sarcoidosis is a systemic inflammatory disorder of unknown causes. Cultures of in biopsy samples of sarcoidosis patients, its presence in BAL fluid, tissue samples as well as antibodies against this bacterium found in serum of patients with sarcoidosis suggest an etiological role in this disease. In this review we address the antigenic as well as immunomodulatory potential of with a focus on sarcoidosis. Furthermore, a potential role for antibiotic treatment in patients with sarcoidosis will be explored.
（以前称为 ）被认为是人类皮肤以及粘膜表面的非致病性常驻菌。然而，也已证明其在寻常痤疮或骨科手术后植入物感染等疾病中起致病作用。除了在传染病中的作用外，通过使用 增强各种癌症的抗肿瘤活性或疫苗接种反应的研究表明，这种细菌似乎还具有免疫调节作用。结节病是一种病因不明的全身性炎症性疾病。结节病患者活检样本中的 培养物、其在支气管肺泡灌洗（BAL）液、组织样本中的存在以及结节病患者血清中发现的针对这种细菌的抗体表明其在该疾病中具有病因学作用。在本综述中，我们将探讨 的抗原性以及免疫调节潜力，重点关注结节病。此外，还将探讨抗生素治疗在结节病患者中的潜在作用。
