Milner R J, Picard J, Tustin R
Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
J S Afr Vet Assoc. 1997 Dec;68(4):147-9. doi: 10.4102/jsava.v68i4.898.
A 3-year-old German shepherd dog was presented with a history of lifelong episodic diarrhoea. An adverse reaction to food was considered the most likely cause of the diarrhoea. The dog had received prolonged antibiotic therapy for most of its life as well as receiving probiotics containing the yeast Saccharomyces cerevisiae (syn. S. boulardi) for a year before referral. The probiotic was discontinued 2 months before to referral. Examination and culture of faecal samples identified yeast-like organisms, S. cerevisiae and Candida famata. S. cerevisiae has been isolated from humans in association with predisposing conditions such as prolonged sojourns in hospital, immunosuppression, broad-spectrum antibiotic therapy and prosthetic devices, but is regarded as non-pathogenic in humans and is rarely associated with disease in animals. C. famata has been isolated from animals, humans and the environment, but is regarded as a very rare pathogen. No evidence of immunosuppression was found in the dog. The presence of yeasts in the faecal isolates and the history of prolonged use of antibiotics and probiotics with a concurrent adverse reaction to food, suggest that conditions may have occurred within the bowel that made it possible for the yeasts to colonise parts of it. This has apparently not been reported before.
一只3岁的德国牧羊犬因终生间歇性腹泻前来就诊。食物不良反应被认为是腹泻最可能的原因。这只狗一生中大部分时间都接受了长期抗生素治疗，转诊前一年还接受了含有酿酒酵母（同义词：布拉迪酵母）的益生菌。转诊前2个月停用了益生菌。粪便样本检查和培养发现了酵母样微生物、酿酒酵母和法塔假丝酵母。酿酒酵母已从人类中分离出来，与诸如长期住院、免疫抑制、广谱抗生素治疗和假体装置等易感因素有关，但在人类中被视为非致病性，在动物中很少与疾病相关。法塔假丝酵母已从动物、人类和环境中分离出来，但被视为非常罕见的病原体。在这只狗身上未发现免疫抑制的证据。粪便分离物中存在酵母，以及长期使用抗生素和益生菌并伴有食物不良反应的病史，表明肠道内可能出现了使酵母能够在其中部分部位定植的条件。此前显然没有关于此的报道。
