Iwasa M, Kinosada Y, Watanabe S, Furuta M, Yuda H, Kawamura N, Nakayabu M, Esaki A, Sato T, Deguchi T, Nakatsuka A, Adachi Y
Department of Internal Medicine, Kuwana Municipal Hospital, Mie, Japan.
Neuroradiology. 1998 Mar;40(3):145-9. doi: 10.1007/s002340050555.
The magnetisation transfer ratio (MTR), a quantitative tissue characteristic, and the pallidal index were measured in the globus pallidus of 37 patients with hepatic cirrhosis and 37 control subjects. The MTR decreased with severity of the disease, as indicated by the serum total bililubin, indocyanine green 15-min retention rate, and plasma ammonia. The pallidal index correlated significantly with haematological parameters, although the correlation coefficients tended to be lower than those between MTR and haematological parameters. This change in MTR corresponded to the results of the manganese chloride experiments. T1 shortening in the pallidum of patients with cirrhosis is presumably caused by paramagnetic effects, and possibly attributed to manganese deposition.
在37例肝硬化患者和37例对照者的苍白球中测量了磁化传递率（MTR，一种定量组织特征）和苍白球指数。MTR随疾病严重程度降低，疾病严重程度通过血清总胆红素、吲哚菁绿15分钟潴留率和血浆氨来表示。苍白球指数与血液学参数显著相关，尽管相关系数往往低于MTR与血液学参数之间的相关系数。MTR的这种变化与氯化锰实验结果一致。肝硬化患者苍白球的T1缩短可能是由顺磁效应引起的，并且可能归因于锰沉积。
