Suresh Babu P, Srinivasan K
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India.
Mol Cell Biochem. 1998 Apr;181(1-2):87-96. doi: 10.1023/a:1006821828706.
Curcumin, the coloring principle of the commonly used spice turmeric (Curcuma longa) was fed at 0.5% in the diet to streptozotocin-induced diabetic Wistar rats for 8 weeks. Renal damage was assessed by the amount of proteins excreted in the urine and the extent of leaching of renal tubular enzymes: NAG, LDH, AsAT, AlAT, alkaline and acid phosphatases. The integrity of kidney was assessed by measuring the activities of several key enzymes of the renal tissue: glucose-6-phosphate dehydrogenase, glucose-6-phosphatase, and LDH (Carbohydrate metabolism), aldose reductase and sorbitol dehydrogenase (polyol pathway), transaminases, ATPases and membrane PUFA/SFA ratio (membrane integrity). Data on enzymuria, albuminuria, activity of kidney ATPases and fatty acid composition of renal membranes in diabetic condition suggested that dietary curcumin brought about significant beneficial modulation of the progression of renal lesions in diabetes. These findings were also corroborated by histological examination of kidney sections. It is inferred that this beneficial ameliorating influence of dietary curcumin on diabetic nephropathy is possibly mediated through its ability to lower blood cholesterol levels.
姜黄素是常用香料姜黄（姜黄属植物）的色素成分，以0.5%的比例添加到链脲佐菌素诱导的糖尿病Wistar大鼠的饮食中，持续8周。通过尿液中蛋白质的排泄量以及肾小管酶（NAG、LDH、AsAT、AlAT、碱性磷酸酶和酸性磷酸酶）的渗漏程度来评估肾脏损伤。通过测量肾组织中几种关键酶的活性来评估肾脏的完整性：葡萄糖-6-磷酸脱氢酶、葡萄糖-6-磷酸酶和LDH（碳水化合物代谢）、醛糖还原酶和山梨醇脱氢酶（多元醇途径）、转氨酶、ATP酶以及膜多不饱和脂肪酸/饱和脂肪酸比例（膜完整性）。关于糖尿病状态下的酶尿、蛋白尿、肾脏ATP酶活性以及肾膜脂肪酸组成的数据表明，饮食中的姜黄素对糖尿病肾脏病变的进展产生了显著的有益调节作用。肾脏切片的组织学检查也证实了这些发现。据推测，饮食中的姜黄素对糖尿病肾病的这种有益改善作用可能是通过其降低血液胆固醇水平的能力介导的。
