通过31P-MR波谱法测量的MELAS患者光刺激引起的脑能量代谢改变。
Photic stimulation-induced alteration of brain energy metabolism measured by 31P-MR spectroscopy in patients with MELAS.
作者信息
Kato T, Murashita J, Shioiri T, Terada M, Inubushi T, Kato N
机构信息
Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan.
出版信息
J Neurol Sci. 1998 Mar 5;155(2):182-5. doi: 10.1016/s0022-510x(97)00308-0.
We examined brain energy metabolism by phosphorus-31 magnetic resonance spectroscopy (31P-MRS) in the occipital cortex in a mother and a daughter with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) during photic stimulation. The peak area ratio of phosphocreatine markedly decreased during photic stimulation, and subsequently increased after the stimulation. This method, photic stimulation-31P-MRS, may be useful in assessing brain energy metabolism in neurological diseases.
我们采用磷-31磁共振波谱法（31P-MRS），在光刺激期间对一名患有线粒体肌病、脑病、乳酸酸中毒和卒中样发作（MELAS）的母亲及其女儿的枕叶皮质进行了脑能量代谢检查。在光刺激期间，磷酸肌酸的峰面积比显著降低，随后在刺激后升高。这种光刺激-31P-MRS方法可能有助于评估神经疾病中的脑能量代谢。
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