Schane H P, Potts G O
J Clin Endocrinol Metab. 1978 Sep;47(3):691-4. doi: 10.1210/jcem-47-3-691.
Spironolactone has progestational activity in the rabbit and rhesus monkey. It produced glandular development in the endometrium of the estrogen-primed immature female rabbit over the dosage range of 50 to 200 mg/kg and, at 400 mg/monkey, it delayed estrogen-withdrawal bleeding in ovariectomized monkeys and it inhibited menstruation in regularly cycling monkeys. These data are consistent with the menstrual irregularity and amenorrhea seen in women during treatment with spironolactone.
螺内酯在兔和恒河猴体内具有孕激素活性。在50至200毫克/千克的剂量范围内，它能使雌激素预处理的未成熟雌性兔的子宫内膜出现腺体发育；在400毫克/猴的剂量下，它能延迟去卵巢猴的雌激素撤退性出血，并抑制正常月经周期猴的月经。这些数据与使用螺内酯治疗期间女性出现的月经不调和闭经现象相符。
