Kreitmann B, Bugat R, Bayard F
J Clin Endocrinol Metab. 1979 Dec;49(6):926-9. doi: 10.1210/jcem-49-6-926.
The concentration of the progesterone receptor (PR), both cytosol and nuclear, has been measured in the endometrium of 31 normal menstruating women during the 2 phases of their menstrual cycle and compared with the plasma 17 beta-estradiol and progesterone concentrations. There was no relationship between PR concentrations and the plasma steroid levels when the 2 phases of the cycle were considered; however, a statistically significant correlation (r = 0.70; P less than 0.005) was observed between PR concentration and plasma 17 beta-estradiol when only the follicular phase was considered. PR was then measured in the endometrium of 14 postmenopausal patients treated with ethinylestradiol at increasing doses with or without association of chlormadinone acetate. Ethinylestradiol was shown to increase PR concentration (P less than 0.05), and chlormadinone acetate was found to prevent this increase. These data suggest that in humans, as in other mammalian species, the endometrial PR concentration is under estrogen and progestin control.
在31名正常月经周期女性的子宫内膜中，测量了其月经周期两个阶段的细胞质和细胞核中孕激素受体（PR）的浓度，并与血浆17β-雌二醇和孕激素浓度进行了比较。当考虑月经周期的两个阶段时，PR浓度与血浆类固醇水平之间没有关系；然而，仅考虑卵泡期时，观察到PR浓度与血浆17β-雌二醇之间存在统计学上显著的相关性（r = 0.70；P < 0.005）。然后，在14名绝经后患者的子宫内膜中测量PR，这些患者接受了不同剂量的炔雌醇治疗，部分患者联合或不联合醋酸氯地孕酮。结果显示，炔雌醇可增加PR浓度（P < 0.05），而醋酸氯地孕酮可阻止这种增加。这些数据表明，在人类中，如同在其他哺乳动物物种中一样，子宫内膜PR浓度受雌激素和孕激素的控制。
