Nakajima S T, Brumsted J R, Riddick D H, Gibson M
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington 05405.
Fertil Steril. 1989 Jul;52(1):155-8. doi: 10.1016/s0015-0282(16)60807-5.
Menstrual irregularity is a recognized side effect of spironolactone when used as a treatment for hirsutism in women. This effect has been attributed to the progestational activity of spironolactone observed in animal models. However, when oral spironolactone was given to women with appropriately estrogen-primed endometrium, secretory transformation of the endometrium was absent in comparison with control cycles. When control cycles were repeated with the addition of spironolactone, a decidualized endometrial response was seen. These findings suggest that spironolactone at clinically used dosages does not act as a progestin or an antiprogestin on the human endometrium.
月经不规律是螺内酯用于治疗女性多毛症时公认的副作用。这种作用归因于在动物模型中观察到的螺内酯的孕激素活性。然而，当给子宫内膜已得到适当雌激素预处理的女性口服螺内酯时，与对照周期相比，子宫内膜未出现分泌期转化。当在对照周期中添加螺内酯重复实验时，可见子宫内膜出现蜕膜样反应。这些发现表明，临床使用剂量的螺内酯对人子宫内膜既不发挥孕激素作用，也不发挥抗孕激素作用。
