Alecu M, Coman G, Gălăţescu E
Dermatovenereology Center, Scarlat Longhin Clinical Hospital for Dermatology, Bucharest, Romania.
Rom J Intern Med. 1997 Jan-Dec;35(1-4):83-8.
A 24-patient lot with hypersensitivity vasculitis was investigated for serological determinations of ICAM and ELAM adhesion molecules. Determinations were made in attack and in remission. Over two thirds of the cases presented elevated serological levels of ICAM and ELAM in attack, with twofold higher values than normal. In remission, in the absence of clinical signs, ICAM and ELAM values were normal in 19 cases (ICAM) and 22 cases (ELAM). Serological level of ICAM and ELAM was concordant with serological level of IL-2, IL-6, circulating immune complexes and clinical status. The increased values of ICAM and ELAM are due to the expression of these molecules both on the surface of endothelial cells and on immune cells. The adherence of leukocytes on the endothelial cells, by adhesion molecules involvement, followed by their extravasation represents an important event in the vascular lesion pathogeny of the hypersensitivity vasculitis.
对一组24例超敏性血管炎患者进行了细胞间黏附分子（ICAM）和内皮白细胞黏附分子（ELAM）的血清学检测。在发作期和缓解期都进行了检测。超过三分之二的病例在发作期呈现ICAM和ELAM血清学水平升高，其值比正常高两倍。在缓解期，在无临床症状的情况下，19例（ICAM）和22例（ELAM）的ICAM和ELAM值正常。ICAM和ELAM的血清学水平与白细胞介素-2、白细胞介素-6、循环免疫复合物的血清学水平及临床状态一致。ICAM和ELAM值升高是由于这些分子在内皮细胞表面和免疫细胞上均有表达。通过黏附分子的参与，白细胞在内皮细胞上的黏附，随后发生外渗，这在超敏性血管炎的血管病变发病机制中是一个重要事件。
