Lampe E, de Oliveira J M, Pereira J L, Saback F L, Yoshida C F, Niel C
Department of Virology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Clin Diagn Virol. 1998 Jan;9(1):1-7. doi: 10.1016/s0928-0197(97)10017-4.
The recently discovered hepatitis G virus (HGV) belongs, as hepatitis C virus (HCV), to the Flaviviridae family. HGV has been isolated from the serum of patients with non A-E hepatitis. However, the association of HGV with hepatitis is uncertain.
To determine the HGV prevalence in blood donors and in patients with liver disease and to evaluate a possible correlation between HGV infection and liver disease.
Sera from a total of 113 consecutive patients with chronic liver disease were submitted to a series of liver enzymes and function tests and analyzed for the presence of HBsAg, anti-HBs, anti-HBc, anti-HCV, HCV RNA and HGV RNA. Prevalence of HGV RNA was determined in a group of 87 blood donors.
Nine (10%) sera from blood donors and 15 (13%) sera from patients with chronic liver disease were HGV RNA positive. Some 28 (25%) patients were HCV RNA positive, with genotypes 1a, 1b and 3 present in 10, 12 and 5 patients, respectively. A total of 20 (18%) patients were HBsAg carriers. Five (4%) patients were double infected (one with HBV + HCV, one with HBV + HGV and three with HCV + HGV).
The proportion (10%) of HGV-infected blood donors was very high when compared with other countries. The results did not allow to establish HGV as an etiologic agent for chronic liver disease. The parenteral route was the presumed means of HGV transmission for only one-third of the patients.
最近发现的庚型肝炎病毒（HGV）与丙型肝炎病毒（HCV）一样，属于黄病毒科。HGV已从非甲 - 戊型肝炎患者的血清中分离出来。然而，HGV与肝炎之间的关联尚不确定。
确定献血者和肝病患者中HGV的流行情况，并评估HGV感染与肝病之间可能存在的相关性。
对连续113例慢性肝病患者的血清进行了一系列肝酶和肝功能测试，并分析了HBsAg、抗 - HBs、抗 - HBc、抗 - HCV、HCV RNA和HGV RNA的存在情况。测定了一组87名献血者中HGV RNA的流行率。
9名（10%）献血者的血清和15名（13%）慢性肝病患者的血清HGV RNA呈阳性。约28名（25%）患者HCV RNA呈阳性，其中1a、1b和3型分别存在于10例、12例和5例患者中。共有20名（18%）患者为HBsAg携带者。5名（4%）患者为双重感染（1例为HBV + HCV，1例为HBV + HGV，3例为HCV + HGV）。
与其他国家相比，HGV感染的献血者比例（10%）非常高。结果不允许将HGV确立为慢性肝病的病原体。仅三分之一的患者推测经肠道外途径传播HGV。
