Bagger J P, Jensen B S, Johannsen G
Department of Cardiology, Skejby University Hospital, Aarhus, Denmark.
Clin Cardiol. 1998 Apr;21(4):286-8. doi: 10.1002/clc.4960210410.
Treatment of patients with refractory chest pain remains a challenge. In this study, the long-term clinical effects of spinal cord electrical stimulation were evaluated in 10 consecutive male patients (mean age 53.7 years) with chronic chest pain in a prospective observational study.
After placement of the electrode in an epidural position and before implantation of the device, patients were subjected to clinical evaluation, including atrial pacing, in order to document significant antianginal effects.
Spinal cord electrical stimulation abolished or improved pacing time to angina by more than 50% in seven of the patients who subsequently had the device implanted. In three of these patients, the system was ineffective after a period of 3-9 months despite paresthesia in the area of anginal pain with electrical stimulation. The effects of treatment remained satisfactory in the remaining patients (40%) after a mean follow-up of 60 (45-72) months. Thus, a long-lasting clinical response was able to be predicted in 57% of the patients.
Spinal cord electrical stimulation is one of the few therapeutic options in inoperable patients with refractory chest pain.
难治性胸痛患者的治疗仍是一项挑战。在本前瞻性观察研究中，对10例连续的慢性胸痛男性患者（平均年龄53.7岁）评估了脊髓电刺激的长期临床效果。
在将电极置于硬膜外位置后且在植入装置前，患者接受包括心房起搏在内的临床评估，以记录显著的抗心绞痛效果。
在随后植入装置的7例患者中，脊髓电刺激使心绞痛发作的起搏时间减少或改善超过50%。在其中3例患者中，尽管电刺激时心绞痛疼痛区域有感觉异常，但3至9个月后该系统无效。其余患者（40%）在平均随访60（45 - 72）个月后治疗效果仍令人满意。因此，57%的患者能够预测到持久的临床反应。
脊髓电刺激是难治性胸痛无法手术患者的少数治疗选择之一。
