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脊髓圆锥刺激治疗难治性阴部神经痛:27例连续病例的前瞻性研究

Spinal cord stimulation of the conus medullaris for refractory pudendal neuralgia: a prospective study of 27 consecutive cases.

作者信息

Buffenoir Kevin, Rioult Bruno, Hamel Olivier, Labat Jean-Jacques, Riant Thibault, Robert Roger

机构信息

Department of Neurosurgery and Neurotraumatology, CHU de Nantes, Nantes, France; Pain, Neuromodulation, and Quality of Life, INSERM EA3826, Nantes, France.

出版信息

Neurourol Urodyn. 2015 Feb;34(2):177-82. doi: 10.1002/nau.22525. Epub 2013 Nov 19.

Abstract

AIMS

Thirty percent of patients with pudendal neuralgia due to pudendal nerve entrapment obtain little or no relief from nerve decompression surgery. The objective was to describe the efficacy of spinal cord stimulation of the conus medullaris in patients with refractory pudendal neuralgia.

METHODS

This prospective study, conducted by two centers in the same university city, described the results obtained on perineal pain and functional disability in all patients with an implanted conus medullaris stimulation electrode for the treatment of refractory pudendal neuralgia. Twenty-seven consecutive patients were included by a multidisciplinary pelvis and perineal pain clinic between May 2011 and July 2012. Mean follow-up was 15 months. The intervention was an insertion of a stimulation electrode was followed by a test period (lasting an average of 13 days) before deciding on permanent electrode implantation. Maximum and average perineal pain scores and the pain-free sitting time were initially compared during the test and in the long-term (paired t-test). The estimated percent improvement (EPI) was evaluated in the long-term.

RESULTS

Twenty of the 27 patients were considered to be responders to spinal cord stimulation and 100% of implanted patients remained long-term responders (mean tripling of sitting time, and mean EPI of 55.5%).

CONCLUSIONS

Spinal cord stimulation of the conus medullaris is a safe and effective technique for long-term treatment of refractory pudendal neuralgia. Routine use of this technique, which has never been previously reported in the literature in this type of patient, must now be validated by a larger scale study.

摘要

目的

因阴部神经卡压导致阴部神经痛的患者中,有30%在接受神经减压手术后疼痛缓解甚微或根本没有缓解。本研究的目的是描述脊髓圆锥刺激术治疗难治性阴部神经痛患者的疗效。

方法

本前瞻性研究由同一大学城的两个中心进行,描述了所有植入脊髓圆锥刺激电极以治疗难治性阴部神经痛患者的会阴疼痛和功能障碍情况。2011年5月至2012年7月期间,一个多学科骨盆与会阴疼痛诊所连续纳入了27例患者。平均随访时间为15个月。干预措施是先插入刺激电极,然后进行为期(平均13天)的测试期,再决定是否永久植入电极。最初在测试期和长期随访时比较最大和平均会阴疼痛评分以及无痛坐位时间(配对t检验)。评估长期的估计改善百分比(EPI)。

结果

27例患者中有20例被认为对脊髓刺激有反应,100%的植入患者长期有反应(坐位时间平均增加两倍,平均EPI为55.5%)。

结论

脊髓圆锥刺激术是一种安全有效的技术,可长期治疗难治性阴部神经痛。这种技术此前从未在该类患者的文献中报道过,其常规应用现在必须通过更大规模的研究来验证。

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