Gas-liquid chromatographic determination of tienilic acid (SKF 62.698) in human plasma and urine.
作者信息
Desager J P, Vanderbist M
出版信息
J Chromatogr. 1976 Aug 4;123(2):379-84. doi: 10.1016/s0021-9673(00)82206-2.
PMID:956314
Abstract
A gas-liquid chromatographic method is described for the determination of tienilic acid (SKF 62.698), a diuretic with uricosuric properties, in human plasma and urine. The method, which is based on the methylation of the compound, is rapid, specific and sensitive. The lowest level accurately determined is about 50 ng/ml in plasma and 1 mug/ml in urine. The first results from a human volunteer are given.
摘要
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Gas-liquid chromatographic determination of tienilic acid (SKF 62.698) in human plasma and urine.
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引用本文的文献
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Metabolism of tienilic acid (ticrynafen) in man. Pharmacokinetic and mass spectrometric studies.
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