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阿片类成瘾者中苯二氮䓬类药物滥用的检测。

Detection of benzodiazepine abuse in opiate addicts.

作者信息

Browne R, Sloan D, Fahy S, Keating S, Moran C, O'Connor J

机构信息

Drug Treatment Centre Board, Dublin.

出版信息

Ir Med J. 1998 Jan-Feb;91(1):18-9.

PMID:9563249
Abstract

There is an increasing problem with benzodiazepine co-abuse in the opiate dependent population of Dublin. The importance of early detection of this co-abuse is essential as there is an increased risk of dangerous injecting practices such as sharing of needles and criminality in those who co-abuse benzodiazepines and opiates. This study was carried out in the National Drug Treatment Centre, Dublin. It aims to describe the current difficulties in identifying the co-abuse of short acting benzodiazepines including flunitrazepam in a cohort of opiate dependent patients. Using a sample of those attending the clinic it was discovered that standard methods of urinalysis failed to identify 10% of co-abuse. For those patients whose abuse of flunitrazepam is undetected on screening, clinical interventions which aim to minimise the consequence of the co-abuse and reverse the chaotic drug using patterns fail to be put in place at the earliest possible time.

摘要

在都柏林的阿片类药物依赖人群中,苯二氮䓬类药物共同滥用的问题日益严重。早期发现这种共同滥用至关重要,因为在同时滥用苯二氮䓬类药物和阿片类药物的人群中,诸如共用针头之类的危险注射行为及犯罪风险会增加。这项研究在都柏林的国家药物治疗中心开展。其目的是描述在一组阿片类药物依赖患者中识别包括氟硝西泮在内的短效苯二氮䓬类药物共同滥用目前存在的困难。通过对前来诊所就诊的患者进行抽样发现,标准尿液分析方法未能识别出10%的共同滥用情况。对于那些筛查时未检测出滥用氟硝西泮的患者,旨在将共同滥用后果降至最低并扭转混乱用药模式的临床干预措施无法尽早实施。

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引用本文的文献

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BMC Psychiatry. 2011 May 19;11:90. doi: 10.1186/1471-244X-11-90.
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Two types of classification for male opioid dependence: identification of an opioid addict with depressive features.男性阿片类药物依赖的两种分类:具有抑郁特征的阿片类成瘾者的识别。
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The detection and quantitation of 7-aminoflunitrazepam, the major urinary metabolite of flunitrazepam, by gas chromatography/mass spectrometry.
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Ir J Med Sci. 1999 Jul-Sep;168(3):189-92. doi: 10.1007/BF02945851.