Saber A T, Nielsen L R, Dictor M, Hagmar L, Mikoczy Z, Wallin H
National Institute of Occupational Health, Copenhagen, Denmark.
Cancer Lett. 1998 Apr 10;126(1):59-65. doi: 10.1016/s0304-3835(97)00536-3.
Of 39 males diagnosed with sinonasal adenocarcinomas over 30 years in the Lund University Hospital catchment area (1.5 million inhabitants), archival tumor tissue was available from 29. Of these, 16 had been exposed to wood dust and three had been exposed to leather dust. The intestinal-type and papillary adenocarcinomas were more common in the exposed patients (P = 0.0002, Fisher's exact test). The tumors from all but one of the 29 sinonasal adenocarcinomas could be analyzed for point mutations at codons 12, 13 and 61 of the K-ras gene. Four mutations were detected in the 28 tumors. The three mutations in the patients exposed to wood and leather dust were all G:C --> A:T transitions, with two at position 2 of codon 12 and one at position 2 of codon 13. The high proportion of G:C --> A:T mutations in this rare tumor may reflect a genotoxic agent in wood and leather dust.
在隆德大学医院服务区域（150万居民）内，30年间被诊断为鼻窦腺癌的39名男性患者中，有29名患者留存有存档肿瘤组织。其中，16名曾接触木屑粉尘，3名曾接触皮革粉尘。肠型和乳头状腺癌在接触粉尘的患者中更为常见（P = 0.0002，Fisher精确检验）。除1例鼻窦腺癌外，其余28例肿瘤均可分析K-ras基因第12、13和61密码子的点突变情况。在这28例肿瘤中检测到4个突变。接触木屑和皮革粉尘患者中的3个突变均为G:C→A:T转换，其中2个位于第12密码子第2位，1个位于第13密码子第2位。在这种罕见肿瘤中，G:C→A:T突变的高比例可能反映了木屑和皮革粉尘中的遗传毒性物质。
