Xiong S K, Okajima Y, Ishikawa K, Watanabe H, Inaba N
Department of Obstetrics and Gynecology, Dokkyo University School of Medicine, Tochigi, Japan.
J Obstet Gynaecol Res. 1998 Feb;24(1):57-61. doi: 10.1111/j.1447-0756.1998.tb00053.x.
To clarify the incidence and risk factors of the vertical transmission of hepatitis C virus (HCV) and to determine the prognosis of the carrier infants.
At our hospital, 1,941 non-pathological (non-HIV carriers) Japanese pregnant women were screened for anti-HCV antibodies. Sera of the antibody-positive women were examined by the reverse transcription polymerase chain reaction (RT-PCR) method, and the positive women and their infants were followed by testing HCV-related markers.
The HCV carrier rate among the pregnant women was 3.5% (68/1,941). Four among the 65 infants (6.2%) who were successfully followed for more than 6 months developed the HCV carrier-state. Of all the risk factors examined, only the elevation (> or = 110 IU/l) of maternal serum alanine aminotransferase (ALT) was found to be significant for HCV vertical transmission. Seventy-five and 50% of the carrier infants manifested chemical hepatitis and seroconverted to an HCV-RNA-negative status, respectively, during the follow-up period.
The frequency of HCV vertical transmission was 6.2%. Half of the carrier infants became seronegative for HCV-RNA. HCV vertical transmission was significantly affected by the maternal serum ALT level prior to delivery.
明确丙型肝炎病毒（HCV）垂直传播的发生率及危险因素，并确定携带HCV婴儿的预后情况。
在我院，对1941名非病理性（非HIV携带者）日本孕妇进行了抗HCV抗体筛查。对抗体阳性女性的血清采用逆转录聚合酶链反应（RT-PCR）法进行检测，并对阳性女性及其婴儿进行HCV相关标志物检测以进行随访。
孕妇中的HCV携带率为3.5%（68/1941）。在成功随访6个月以上的65名婴儿中，有4名（6.2%）发展为HCV携带状态。在所有检测的危险因素中，仅发现母亲血清丙氨酸转氨酶（ALT）升高（≥110 IU/l）与HCV垂直传播显著相关。在随访期间，分别有75%和50%的携带HCV婴儿出现化学性肝炎并血清转化为HCV-RNA阴性状态。
HCV垂直传播的发生率为6.2%。一半的携带HCV婴儿HCV-RNA转为阴性。分娩前母亲血清ALT水平对HCV垂直传播有显著影响。
