Hamersley S L, Landy H J, O'Sullivan M J
Department of Obstetrics and Gynecology, University of Miami Medical School, Miami, Florida, USA.
J Reprod Med. 1998 Mar;43(3):206-10.
Alterations in fetal heart rate variability and baseline may be seen with maternal administration of magnesium sulfate. In this case, a dose-related decrease in the baseline fetal heart rate was observed in association with magnesium sulfate administration.
A primiparous woman was given parenteral magnesium sulfate for preterm labor. After tocolytic administration, the fetal heart rate baseline decreased to 110 beats per minute (bpm) from its initial rate of 140 bpm, although good variability was maintained. Increasing the dosage was accompanied by a further drop in the baseline heart rate, to 100 bpm. Fetal echocardiography was normal except for sinus bradycardia. Stopping magnesium sulfate administration was accompanied by a return to the pretherapy baseline heart rate. The pregnancy progressed without any further complications, and a healthy infant was delivered three weeks later.
Maternal administration of magnesium sulfate may be associated with a profound decrease in the baseline fetal heart rate, resulting in fetal sinus bradycardia.
孕妇使用硫酸镁可能会导致胎儿心率变异性和基线的改变。在本病例中，观察到与硫酸镁给药相关的胎儿心率基线呈剂量相关性下降。
一名初产妇因早产接受硫酸镁肠外给药。在使用宫缩抑制剂后，胎儿心率基线从初始的140次/分钟降至110次/分钟，尽管仍保持良好的变异性。增加剂量后，基线心率进一步下降至100次/分钟。除窦性心动过缓外，胎儿超声心动图正常。停止使用硫酸镁后，心率恢复到治疗前的基线水平。妊娠过程中未出现任何进一步并发症，三周后分娩出一名健康婴儿。
孕妇使用硫酸镁可能会导致胎儿心率基线显著下降，从而引起胎儿窦性心动过缓。
