Jamkhedkar P P, Hira S K, Shroff H J, Lanjewar D N
Department of Skin/STD, Sir J. J. Hospital, Mumbai, India.
Sex Transm Dis. 1998 Apr;25(4):196-200. doi: 10.1097/00007435-199804000-00004.
Granuloma Inguinale (GI) is an endemic sexually transmitted disease (STD) in India. With increasing prevalence of human immunodeficiency virus (HIV) among patients with STD at a clinic in Mumbai, a study was conducted to determine clinico-epidemiologic features of GI and HIV.
To determine possible interaction between GI and HIV.
Prospective follow-up of 21 consecutive cases (GI in HIV-seropositive individuals) and 29 controls (GI in HIV-seronegative individuals) to determine time to heal. All cases and controls received a standard treatment regimen of erythromycin, 2 g po daily, under supervision until healing occurred.
Although GI ulcers at recruitment were not significantly larger among HIV-seropositive individuals as compared with those seen among HIV-seronegative individuals (mean size 4.4 cm2 vs. 3.6 sq2; odds ratio [OR] 1.22, confidence interval [CI] .95, 0.63, 2.40; p = 0.52), the former took longer time to heal completely (mean 25.7 days vs. 16.8 days; OR 1.82, CI .95, 0.99, 3.36; p = 0.03) and tended to produce greater tissue destruction (as included in results).
These findings are important because slow-healing GI ulcers with underlying HIV infection, which may be caused by their interaction, will lead to increased transmission of both the infections.
腹股沟肉芽肿（GI）是印度一种地方性传播疾病（STD）。随着孟买一家诊所性传播疾病（STD）患者中人类免疫缺陷病毒（HIV）患病率的上升，开展了一项研究以确定GI和HIV的临床流行病学特征。
确定GI与HIV之间可能的相互作用。
对21例连续病例（HIV血清阳性个体中的GI）和29例对照（HIV血清阴性个体中的GI）进行前瞻性随访以确定愈合时间。所有病例和对照在监督下接受标准治疗方案，即每日口服2g红霉素，直至愈合。
尽管与HIV血清阴性个体相比，HIV血清阳性个体在入组时的GI溃疡面积并无显著增大（平均面积4.4平方厘米对3.6平方厘米；优势比[OR]1.22，置信区间[CI].95，0.63，2.40；p = 0.52），但前者完全愈合所需时间更长（平均25.7天对16.8天；OR 1.82，CI.95，0.99，3.36；p = 0.03），且往往会造成更大的组织破坏（结果中有所体现）。
这些发现很重要，因为潜在HIV感染导致的愈合缓慢的GI溃疡，可能是由它们之间的相互作用引起的，这将导致两种感染的传播增加。
