蓖麻毒素和相思子毒素介导的膜融合
Membrane fusion mediated by ricin and viscumin.
作者信息
Pohl P, Antonenko Y N, Evtodienko V Y, Pohl E E, Saparov S M, Agapov I I, Tonevitsky A G
机构信息
Martin Luther Universität, Medizinische Fakultät, Institut für Medizinische Physik und Biophysik, 06097 Halle, Germany.
出版信息
Biochim Biophys Acta. 1998 Apr 22;1371(1):11-6. doi: 10.1016/s0005-2736(98)00024-8.
The ribosome inactivating plant proteins (RIPs) ricin and viscumin but not Ricinus communis agglutinin are able induce vesicle-vesicle fusion. A model is suggested in which the toxicity of the RIPs is partially determined by their fusogenicity. Herein, fusion is hypothesized to allow the RIPs to leak across endocytic vesicles to approve their access to cytoplasmic ribosomes.
核糖体失活植物蛋白（RIPs）中的蓖麻毒素和相思豆毒素能诱导囊泡-囊泡融合，但蓖麻凝集素不能。有人提出了一个模型，其中RIPs的毒性部分由其融合性决定。在此，推测融合作用使RIPs能够穿过内吞囊泡泄漏，从而使其能够接触到细胞质核糖体。
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