Smythies J, Galzigna L
Institute of Neurology, Queen Square, London WC1 3BG, UK.
Biochim Biophys Acta. 1998 Apr 10;1380(2):159-62. doi: 10.1016/s0304-4165(97)00131-1.
This paper summarizes the strong evidence that we now have that the oxidative pathway of metabolism of the catecholamines, dopamine and norepinephrine via their respective quinones occurs in vivo in the brain. This fact is not yet widely appreciated. The evidence is based on the chemical structure of neuromelanin, advanced mass spectrometry techniques and the identification of intermediates of this system, such as 5-cysteinyl dopamine, in the brain. Supportive evidence is presented from a number of sources including enzymology. A suggestion as to the possible normal function of this system is made.
