Tse D C, McCreery R L, Adams R N
J Med Chem. 1976 Jan;19(1):37-40. doi: 10.1021/jm00223a008.
The possibility that catecholamines can be oxidized via aberrant pathways in vivo is open to question, but in vitro oxidation via aerobic manipulations is established. Assuming oxidation does occur, we have examined quantitatively the fast chemical reactions of the initial oxidation products, the o-quinones. The nature and rates of these reactions were studies under the conditions simulating closely those which presumably exist in mammalian brain. The results are in close accord with existing literature and especially support oxidation pathways recently reported in [3H]-norepinephrine binding to particulate cell fractions.
儿茶酚胺在体内是否能通过异常途径被氧化尚存在疑问，但通过需氧操作进行的体外氧化已得到证实。假设氧化确实发生，我们已对初始氧化产物邻醌的快速化学反应进行了定量研究。这些反应的性质和速率是在与哺乳动物大脑中可能存在的情况非常相似的条件下进行研究的。结果与现有文献高度一致，尤其支持了最近在[3H] - 去甲肾上腺素与颗粒细胞组分结合的研究中报道的氧化途径。
