Scalfaro P, Chesaux J J, Buchwalder P A, Biollaz J, Micheli J L
Division of Neonatology, University Hospital, Lausanne, Switzerland.
Intensive Care Med. 1998 Mar;24(3):247-50. doi: 10.1007/s001340050558.
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
孕期、分娩期及产后使用齐多夫定（ZDV）治疗可有效降低人类免疫缺陷病毒的母婴传播。据报道，长期治疗期间新生儿出现的不良反应为骨髓抑制和天冬氨酸转氨酶活性升高。我们报告1例新生儿严重的ZDV相关性乳酸酸中毒病例，停用ZDV后迅速缓解。导致这种副作用的机制尚不清楚。
