Wada M, Kawata T, Yamada K, Funada U, Kuwamori M, Endo M, Tanaka N, Tadokoro T, Maekawa A
Department of Nutrition, Faculty of Agriculture, Tokyo University of Agriculture, Japan.
Int J Vitam Nutr Res. 1998;68(2):94-7.
As a clue to clarifying the role of vitamin B12 (B12) in the function of the complement system, serum C3 content was determined in B12-deficient rats, and the effect of the administration of methylcobalamin (CH3-B12) on the serum C3 content was also studied. It was found that the serum C3 content in rats fed on a vitamin B12-deficient diet for 90 and 120 days significantly decreased compared with that in control rats. The administration of CH3-B12) restored the serum C3 content to control levels. The above results indicate that B12-deficiency depressed the serum C3 content and lowered humoral immunocompetence, and that these changes were ascribable to B12-deficiency.
为了阐明维生素B12（B12）在补体系统功能中的作用，我们测定了维生素B12缺乏大鼠的血清C3含量，并研究了甲基钴胺素（CH3-B12）给药对血清C3含量的影响。结果发现，与对照大鼠相比，喂食维生素B12缺乏饮食90天和120天的大鼠血清C3含量显著降低。给予CH3-B12可使血清C3含量恢复到对照水平。上述结果表明，维生素B12缺乏会降低血清C3含量并降低体液免疫能力，且这些变化归因于维生素B12缺乏。
