Emerson T S, Keiler J
Marquette General Hospital Regional Medical Center, Department of Hyperbaric Medicine, Michigan, USA.
Undersea Hyperb Med. 1998 Spring;25(1):27-32.
Pattern shift visual evoked potential (PSVEP) N75 and P100 latencies were evaluated as an objective, widely available and rapid test of brain dysfunction in a group of 11 patients in the acute phase (first 6 h) of mild-to-moderate carbon monoxide (CO) poisoning. N75 and P100 latency results were compared to nearly simultaneously obtained standard CO Neuropsychological Screening Battery (CONSB). Patients were sought in whom treatment decisions concerning hyperbaric oxygen (HBO2) vs. normobaric oxygen (NBO2) might be difficult, and were excluded from the study if confounding variables existed for CONSB or PSVEP. N75 and P100 latencies were also obtained after completion of NBO2 or HBO2 therapies. Only one patient, judged clinically to have the mildest poisoning in the series, had significantly abnormal initial PSVEP latencies. This patient's simultaneous CONSB was normal and the abnormal PSVEP latencies failed to normalize post treatment with NBO2. PSVEP latencies were not found to be a sensitive screening tool for treatment decision making in a group of acutely CO poisoned patients where treatment decisions might be difficult.
在一组11例轻至中度一氧化碳（CO）中毒急性期（最初6小时）的患者中，模式翻转视觉诱发电位（PSVEP）的N75和P100潜伏期被评估为一种客观、广泛可用且快速的脑功能障碍检测方法。将N75和P100潜伏期结果与几乎同时获得的标准CO神经心理筛查量表（CONSB）进行比较。寻找那些在高压氧（HBO2）与常压氧（NBO2）治疗决策上可能存在困难的患者，若存在影响CONSB或PSVEP的混杂变量，则将其排除在研究之外。在NBO2或HBO2治疗完成后也获取了N75和P100潜伏期。在该系列中，只有一名临床上判断为中毒最轻的患者，其初始PSVEP潜伏期显著异常。该患者同时进行的CONSB结果正常，且异常的PSVEP潜伏期在NBO2治疗后未恢复正常。在一组急性CO中毒且治疗决策可能存在困难的患者中，PSVEP潜伏期并非治疗决策的敏感筛查工具。
