Ducassé J L, Celsis P, Marc-Vergnes J P
Unité INSERM U 230, CHU Purpan, Toulouse, France.
Undersea Hyperb Med. 1995 Mar;22(1):9-15.
Twenty-six non-comatose patients with acute carbon monoxide (CO) poisoning were randomized into two groups. Both groups were treated as soon as possible and for 2 h, the first group by 100% normobaric oxygen (NBO) and the second by 100% hyperbaric oxygen. At the end of this period, patients treated by HBO had a significant improvement of their clinical and biological conditions compared with patients treated with NBO. Both groups then received the same NBO therapy for 10 h. At the end of this second period, carboxyhemoglobin level was normal in both groups. However, patients treated with NBO showed some clinical impairments, and 3 wk after onset had significantly more electroencephalogram abnormalities and a reduced cerebral blood flow reactivity to acetazolamide. We conclude that HBO reduces the time of initial recovery and the number of delayed functional abnormalities in non-comatose patients with acute CO poisoning. A practical scheme for the use of NBO and HBO in such patients is proposed.
26名非昏迷急性一氧化碳（CO）中毒患者被随机分为两组。两组均尽快接受治疗，持续2小时，第一组采用100%常压氧（NBO）治疗，第二组采用100%高压氧治疗。在此阶段结束时，与接受NBO治疗的患者相比，接受高压氧治疗的患者临床和生物学状况有显著改善。然后两组均接受相同的NBO治疗10小时。在第二阶段结束时，两组的碳氧血红蛋白水平均恢复正常。然而，接受NBO治疗的患者出现了一些临床损伤，发病3周后脑电图异常明显增多，对乙酰唑胺的脑血流反应性降低。我们得出结论，高压氧可缩短非昏迷急性CO中毒患者的初始恢复时间，并减少延迟性功能异常的数量。本文还提出了在这类患者中使用常压氧和高压氧的实用方案。
